Recent advancements in high throughput sequencing technologies have enabled cancer researchers to investigate the complex interplay between biomolecules, giving rise to tumorigenesis, cancer development, and metastasis. Towards developing a mechanistic understanding of such phenomena, and deciphering the exact role of specific biomolecular entities within them, data integrative approaches can be quite helpful. TISON team aims to address the challenge offered by cancer, by leveraging data integrative approaches that cut across disciplines. Specifically, TISON assists in developing cancer systems biology models, simulations, and associated data analyses toward precision medicine and personalized cancer therapeutics.