Features
Editors
TISON performs an intergrative modeling of biomolecular networks, microenvironments, cell decision circuits, in silico cell lines, and organoid geometries. This in combination with a high performance simulation engine core and accompanying data analysis tools, equips investigations into complex multi-scale models.
Networks Editor
Networks Editor helps with the construction of biomolecular interaction networks of genes, transcripts, proteins, and metabolites. Users can design and analyze rules-based and weight-based biomolecular networks towards predicting cell fate outcomes which can be visualized as three-dimensional attractor landscapes.
Therapeutics Editor
Therapeutics Editor assists in undertaking a therapeutic evaluation of biomolecular networks constructed earlier using the Networks Editor. Editor allows the development of therapeutic screens towards identification of novel drug targets, drug repurposing, and personalized therapeutics.
Donors
Publications
Atlantis - Attractor Landscape Analysis Toolbox for Cell Fate Discovery and Reprogramming
Scientific Reports - Nature
CanSeer: A Method for Development and Clinical Translation of Personalized Cancer Therapeutics
bioRxiv - the preprint server for Biology
Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized Therapeutics
Frontiers in Oncology - Special Issue on "Combinatorial Approaches for Cancer Treatment: from Basic to Translational Research"
A Personalized Therapeutics Approach Using an In silico Drosophila Patient Model Reveals Optimal Chemo- and Targeted Therapy Combinations for Colorectal Cancer
Frontiers in Oncology - Special Issue on "Combinatorial Approaches for Cancer Treatment: from Basic to Translational Research"
